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Kevin Stachelek
· Ph.D Candidate, University of Southern California
stachele@usc.edu ·
stchlk.rbind.io ·
orcidID ·
Github ·
bluesky
Last updated on 2025-02-05
Education
PhD Candidate, Cancer Biology and Genomics
University of Southern California, Los Angeles, CA
hideme
2018 — 2024
M.S. Translational Biotechnology
University of Southern California, Los Angeles, CA
hideme
2015 — 2018
B.A. Biology
University of Southern California, Los Angeles, CA
hideme
2009 — 2013
Professional Experience
Doctoral Researcher
University of Southern CaliforniaPI: David Cobrinik
hideme
2018 — 2024
- Conducted studies of retinoblastoma transcriptomics by single cell analysis. Performed bioinformatic analyses of human retinal development and retinoblastoma cancer research in the laboratory of Dr. David Cobrinik at Children’s Hospital Los Angeles. Published one first-author and nine secondary author publications in which I led bioinformatics analyses.
Technician
Children’s Hospital Los AngelesPI: David Cobrinik
hideme
2013 — 2018
- Conducted studies of retinoblastoma transcriptomics by single cell analysis. Performed bioinformatic analyses of human retinal development and retinoblastoma cancer research in the laboratory of Dr. David Cobrinik at Children’s Hospital Los Angeles. Published one first-author and nine secondary author publications in which I led bioinformatics analyses.
Undergraduate Research Assistant
University of Southern CaliforniaPI: John Tower
hideme
2012 — 2013
Grant Support
St. Baldrick’s
hideme
2019 — 2020
Scholarships and Awards
Undergraduate SOAR
hideme
2013 — 2013
Peer-reviewed Publications
Stachelek, K., Harutyunyan, N., Lee, S., Beck, A., Kim, J., Xu, L., Berry, J. L., Nagiel, A., Reynolds, C. P., Murphree, A. L., Lee, T. C., Aparicio, J. G. & Cobrinik, D. Non-Synonymous, Synonymous, and Non-Coding Nucleotide Variants Contribute to Recurrently Altered Biological Processes During Retinoblastoma Progression. Genes Chromosomes Cancer (2022) doi:10.1002/gcc.23120.
N/A
2022
Li, H.-T., Xu, L., Weisenberger, D. J., Li, M., Zhou, W., Peng, C.-C., Stachelek, K., Cobrinik, D., Liang, G. & Berry, J. L. Characterizing DNA methylation signatures of retinoblastoma using aqueous humor liquid biopsy. Nat Commun 13, 5523 (2022).
N/A
2022
Cambier, L., Stachelek, K., Triska, M., Jubran, R., Huang, M., Li, W., Zhang, J., Li, J. & Cobrinik, D. Extracellular vesicle-associated repetitive element DNAs as candidate osteosarcoma biomarkers. Sci Rep 11, 94 (2021).
N/A
2021
Kaneva, K., Merkurjev, D., Ostrow, D., Ryutov, A., Triska, P., Stachelek, K., Cobrinik, D., Biegel, J. A. & Gai, X. Detection of mitochondrial DNA variants at low level heteroplasmy in pediatric CNS and extra-CNS solid tumors with three different enrichment methods. Mitochondrion 51, 97–103 (2020).
N/A
2020
Berry, J. L., Xu, L., Kooi, I., Murphree, A. L., Prabakar, R. K., Reid, M., Stachelek, K., Le, B. H. A., Welter, L., Reiser, B. J., Chévez-Barrios, P., Jubran, R., Lee, T. C., Kim, J. W., Kuhn, P., Cobrinik, D. & Hicks, J. Genomic cfDNA analysis of aqueous humor in retinoblastoma predicts eye salvage: the surrogate tumor biopsy for retinoblastoma. Molecular Cancer Research 16, 1701–1712 (2018).
N/A
2018
Singh, H. P., Wang, S., Stachelek, K., Lee, S., Reid, M. W., Thornton, M. E., Craft, C. M., Grubbs, B. H. & Cobrinik, D. Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors. PNAS 115, E9391–E9400 (2018).
N/A
2018
Kim, J. W., Jacobsen, B., Zolfaghari, E., Ferrario, A., Chevez-Barrios, P., Berry, J. L., Lee, D. K., Rico, G., Madi, I., Rao, N., Stachelek, K., Wang, L.-C. & Gomer, C. Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft. Graefe’s Archive for Clinical and Experimental Ophthalmology 255, (2017).
N/A
2017
Berry, J. L., Xu, L., Murphree, A. L., Krishnan, S., Stachelek, K., Zolfaghari, E., McGovern, K., Lee, T. C., Carlsson, A., Kuhn, P., Kim, J. W., Cobrinik, D. & Hicks, J. Potential of aqueous humor as a surrogate tumor biopsy for retinoblastoma. JAMA Ophthalmology 135, 1221–1230 (2017).
N/A
2017
Stachelek, K., Harutyunyan, N., Lee, S., Harutyunyan, A., Kim, J., Xu, L., Berry, J. L., Nagiel, A., Reynolds, C. P., Murphree, A. L., Lee, T. C., Aparicio, J. G. & Cobrinik, D. Non-Synonymous, synonymous, and non-coding nucleotide variants contribute to recurrently altered biological processes during retinoblastoma progression. Submitted.
N/A
2022
Shayler, D., Stachelek, K., Lee, S., Bai, J., Aparicio, J. G., Kim, Y., Singh, M., Bay, M., Thornton, M., Craft, C., Grubbs, B., Bonaguidi, M., Singh, H., & Cobrinik, David. Single cell transcriptomics reveals novel photoreceptor trajectories and a cancer-predisposed cone precursor state.
N/A
2022
Refereed Presentations
Children’s Blood Disease Institute Annual Retreat 2022
N/A
2022
Biochemistry and Molecular Medicine Annual Retreat 2022
N/A
2022
The Saban Research Institute Science Day 2022
N/A
2022
Keystone Symposium 2019
N/A
2019
Software & Technology
SeuratTools
hideme
2022
Chevreul
hideme
2024
Teaching
Introduction to R: Workshop for incoming PhD students - University of Southern California
hideme
2022
- Led, organized, and co-designed 3-day workshop
Introduction to R: Workshop for incoming PhD students - University of Southern California
hideme
2021
- Led, organized, and co-designed 3-day workshop